a comparative study of pcna and ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma
نویسندگان
چکیده
various cell proliferation markers are used as diagnostic and prognostic tools in oral lesions. simultaneous evaluation of these markers can increase the precision of estimation of the proliferative status of different tissues. in this study we investigated the expression of pcna and ki-67 as markers of cell proliferation in 15 paraffin embedded samples of each dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma belonging to a total of 30 male and 30 female paients using immunohistochemistry method. expression levels based on the intensity and the percentage of stained cells was separately analyzed for each marker with chi-square test, the results of which were significant for the two markers (p< 0.05). the correlation coefficient between the two markers was found to be 0.88. a significant difference in the expression of ki-67 and pcna was observed in the four types of studied lesions.
منابع مشابه
A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma
Various cell proliferation markers are used as diagnostic and prognostic tools in oral lesions. Simultaneous evaluation of these markers can increase the precision of estimation of the proliferative status of different tissues. In this study we investigated the expression of PCNA and Ki-67 as markers of cell proliferation in 15 paraffin embedded samples of each dental follicle, dentigerous cy...
متن کاملA comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma
Various cell proliferation markers are used as diagnostic and prognostic tools in oral lesions. Simultaneous evaluation of these markers can increase the precision of estimation of the proliferative status of different tissues. In this study we investigated the expression of PCNA and Ki-67 as markers of cell proliferation in 15 paraffin embedded samples of each dental follicle, dentigerous cyst...
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Aims: The aim of the current study was to detect and compare Human papillomavirus (HPV) in dentigerous cyst and ameloblastoma. Materials and methods: The study included 32 samples, which distributed into dentigerous cysts (n=16) and ameloblastomas (n=16). Conventional PCR assay using SPF1/2 consensus primers and immunohistochemical analysis were performed for the detection of HPV‒DNA and HPV‒L1...
متن کاملمطالعه ایمونوهیستوشیمیایی Expression نشانگر Ki-67 در آملوبلاستومای تک‌حفره‌ای و کیست دانتی‌ژور
Statement of Problem: Differentiation of dentigerous cyst from unicystic ameloblastoma, discovering any initial ameloblastic changes in lining epithelium of dentigerous cyst at early stage, and differentiation between hyperplastic odontogenic epithelium in fibrous capsule of dentigerous cyst from ameloblastic proliferation, need to an accurate and reliable technique.Purpose: The aim of this stu...
متن کاملExpression of CD105 in tumor angiogenesis a comparative study (ameloblastoma, keratocystic odontogenic tumor and dentigerous cyst)
BACKGROUND Demonstrate the expression of CD105 (angiogenetic marker) in ameloblastoma (AM), keratocystic odontogenic tumor (KCOT) and dentigerous cyst (DC). MATERIAL AND METHODS Assessment of microvessel density (MVD) in 70 cases, including 20 KCOT, 20 DC and 20 solid AMs. Assessment of MVD should be done as the mean number of microvessels per high-power-field. RESULTS AM and KCOT demonstra...
متن کاملCD10 and osteopontin expression in dentigerous cyst and ameloblastoma
AIMS AND OBJECTIVES To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma. METHODS CD10 and osteopontin expression was studied by means of immunohistochemistry in 9 cases of dentigerous cysts (DC) and 17 cases...
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عنوان ژورنال:
international journal of molecular and cellular medicineجلد ۲، شماره ۱، صفحات ۲۷-۳۳
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